How to Make an NFL Prediction Model

Predictions, picks and odds for NFL Week 16 game

Week 16 NFL picks, odds, best bets from proven model: This 5-leg parlay pays nearly 25-1

The NFL playoff picture will begin to take shape as the NFL schedule enters Week 16. The NFC North title may be on the line on Saturday night when Jordan Love and the Green Bay Packers take on Caleb Williams and the Chicago Bears.

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NFL odds, lines, spreads: 2025 Week 16 picks, predictions from proven model: 5-way parlay pays nearly 25-1

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2025 Week 16 NFL games: odds, tips and betting trends

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Self-learning AI releases NFL picks, score predictions every Week 16 game

The Week 16 NFL schedule features 16 more games, including several with potential playoff ramifications.

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NFL power rankings: 3 NFC West teams in top 10 in Week 16

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2025 NFL Week 16 rushing yards predictions and player prop bets

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Seahawks vs. Rams 2025 Prediction, Odds, Picks - Dec 18

The Seahawks are slim favorites (-1.5).

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Cory Curtis: 2025 NFL Week 16 Power Rankings

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Broncos 2025 NFL power rankings tracker: How national experts rank Denver entering Week 16

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Colts vs. Seahawks: Where to watch NFL Week 15, score prediction, betting odds, SGP picks, sportsbook promos

Seattle is a massive home favorite, given that the Colts will be starting a 44-year-old coming off the couch. Indianapolis wins in just 21% of the model's simulations, which offers notable value for the +700 Colts money line. Indy covers the big spread in 56% of the sims and the Over hits 59% of the time.

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